ACE inhibitor - Wikipedia

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As with other angiotensin converting enzyme inhibitors, zofenopril may be less effective in lowering blood pressure in black people than in non-blacks. Angiotensin converting enzyme inhibitors cause a higher rate of angioedema in black patients than in non-black patients. Pregnancy: ACE inhibitors should not be initiated during pregnancy.

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ACE is a monomeric, membrane-bound, zinc- and chloride-dependent peptidyl dipeptidase that catalyzes the conversion of angiotensin (ANG) I to ANG II by removing a carboxy-terminal dipeptide ().More recently, an ACE-related carboxypeptidase (ACE2) has been identified in humans and differs from ACE in that it preferentially removes carboxy-terminal hydrophobic or basic amino acids (2,3).

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Angiotensin-converting-enzyme inhibitors (ACE inhibitors) are a class of medication used primarily for the treatment of high blood pressure and heart failure. They work by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart.. ACE inhibitors inhibit the activity of angiotensin-converting enzyme

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